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This review summarizes GLP-1R action on energy and glucose metabolism, the effectiveness of current GLP-1R agonists on weight loss in T2DM patients, as well as GLP-1R combination therapies

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If these symptoms worsen or become troublesome, contact your GP Body weight : Regular weight monitoring helps assess the effectiveness of your diabetes treatment and can identify unexpected changes Retinal screening : If you have pre-existing diabetic retinopathy, arrange appropriate monitoring as rapid improvements in blood glucose can sometimes temporarily worsen retinopathy When to seek urgent medical help: Severe, persistent abdominal pain (with or without vomiting) contact NHS 111 or seek emergency care (999) as this could indicate pancreatitis or gallbladder disease Signs of dehydration or ketosis due to persistent vomiting or diarrhoea Sudden changes in vision Symptoms of hypoglycaemia (if you are also taking insulin or sulfonylureas) Maintain open communication with your healthcare team about all aspects of your treatment, including any supplements you are taking